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- Title
HAUSP hunting the FOX(O).
- Authors
Huang, Tony T.; D'Andrea, Alan D.
- Abstract
The forkhead box O (FOXO) family of transcription factors regulate cell stress, cell cycle and cell death pathways. Their activities can be modulated by multiple posttranslational modifications, including phosphorylation and acetylation. A recent study adds a new twist to FOXO regulation, showing that coupled ubiquitination and deubiquitination of FOXO may be important for cellular responses to oxidative stress.
- Subjects
TRANSCRIPTION factors; CELL cycle; CELL death; GROWTH factors; POST-translational modification; PHOSPHORYLATION; ACETYLATION; OXIDATIVE stress; GENETIC regulation
- Publication
Nature Cell Biology, 2006, Vol 8, Issue 10, p1043
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1006-1043