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- Title
Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain.
- Authors
Volkow, Nora D.; Fowler, Joanna S.; Logan, Jean; Alexoff, David; Zhu, Wei; Telang, Frank; Wang, Gene-Jack; Jayne, Millard; Hooker, Jacob M.; Wong, Christopher; Hubbard, Barbara; Carter, Pauline; Warner, Donald; King, Payton; Shea, Colleen; Xu, Youwen; Muench, Lisa; Apelskog-Torres, Karen
- Abstract
The article reports on the results of research which was conducted in an effort to measure the acute effects of modafinil on dopamine and dopamine transporters in the male human brain. Researchers used positron emission tomography to measure changes in endogenous dopamine in ten healthy male subjects. They found that modafinil blocked dopamine transporters and increased dopamine in the human brain. Researchers warned that since drugs that increase dopamine have the potential for abuse, there needs to be a heightened awareness for the potential abuse of and dependence on modafinil.
- Subjects
NEUROTRANSMITTERS; DOPAMINE; CATECHOLAMINES; POSITRON emission tomography; BRAIN research; HEALTH outcome assessment; NOOTROPIC agents
- Publication
JAMA: Journal of the American Medical Association, 2009, Vol 301, Issue 11, p1148
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2009.351