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- Title
Short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 rehabilitated dyslipidaemia in diabetic rats.
- Authors
Zhou, Z.‐Y.; Cheng, S.‐P.; Huang, H.; Wang, J.; Pan, H.; Liu, C.‐M.; Xing, C.; Sun, Y.‐L.; Liu, R.‐H.; Zhong, G.‐J.
- Abstract
It was investigated whether short hairpin ribonucleic acid constructs targeting insulin-like growth factor binding protein-3 ( IGFBP-3 sh RNA) can rehabilitate dyslipidaemia in streptozotocin-induced diabetic rats. After 12 weeks of intracavernous administration of IGFBP-3 sh RNA, intracavernous pressure responses to electrical stimulation of cavernous nerves were evaluated. The concentrations of serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and cavernous cyclic guanosine monophosphate were all detected by enzyme-linked immunosorbent assay. The per cent of smooth muscle in corpus cavernous tissue was also evaluated. It was found that the cavernosal pressure was significantly increased in the IGFBP-3 sh RNA treatment group compared to the diabetic control group after 12 weeks of intracavernous administration of IGFBP-3 sh RNA ( P < 0.01). The concentrations of serum low-density lipoprotein cholesterol and triglyceride were significantly decreased in the IGFBP-3 sh RNA treatment group compared to the diabetic control group, while no significant changes of serum high-density lipoprotein cholesterol concentration were found ( P < 0.01). At the same time, cavernous cyclic guanosine monophosphate concentrations and the percentage of cavernosal smooth muscle were both significantly increased in the IGFBP-3 sh RNA treatment group compared to the diabetic control group ( P < 0.01). This study indicated that IGFBP-3 sh RNA might rehabilitate erectile function via a decrease in concentrations of serum low-density lipoprotein and triglyceride, an increase in the percentage of cavernosal smooth muscle and an improvement in the nitric oxide-cyclic guanosine monophosphate signalling activities in streptozotocin-induced diabetic rats.
- Subjects
DIABETES; DYSLIPIDEMIA; INSULIN-like growth factor-binding proteins; RATS
- Publication
Andrologia, 2016, Vol 48, Issue 1, p59
- ISSN
0303-4569
- Publication type
Article
- DOI
10.1111/and.12418