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- Title
Synthesis of New Organotin(IV) N-methyl-N-benzyl Dithiocarbamate Compounds and Cytotoxicity assessment on Human Lung Carcinoma Cell Line (A549).
- Authors
AZIZ, NURUL AMALINA ABD; JAMALUDIN, NUR ATIYAH NADHRAH; AWANG, NORMAH; KAMALUDIN, NURUL FARAHANA; KOK MENG CHAN; ANUAR, NUR NAJMI MOHAMAD
- Abstract
Using the in situ method, the successful synthesis of dibutyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 1) and tricyclohexyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 2) was achieved. Both compounds were characterized by the CHNS elemental analysis, FTIR, NMR spectroscopies and X-ray crystallography study. The experimental CHNS values demonstrated good congruence with the CHNS's theoretical values of the suggested formula structures. The key infrared absorbance peaks, v(C-N) and v(C-S), which were found between 1475-1481 cm-1 and 971-975 cm-1, respectively. The 13C chemical shift of carbon in the NCS2 group was observed in the range of 200.66-202.32 ppm. The crystal structure of Compound 1 shows the anisobidentate's coordination mode between the central metal of the Sn atom and the dithiocarbamate ligands. Compound 1 and Compound 2 have shown great toxicity effects against carcinoma cells in the human lung (A549) with lower IC50 values of 0.80 µM and 2.77 µM, respectively.
- Subjects
CYTOTOXINS; LUNGS; CELL lines; X-ray crystallography; ELEMENTAL analysis; CARCINOMA; CHEMICAL shift (Nuclear magnetic resonance); ATOMS
- Publication
Oriental Journal of Chemistry, 2023, Vol 39, Issue 4, p835
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/390403