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- Title
Synthesis, Spectroscopic Analysis, and In Vitro Anticancer Evaluation of 2-(Phenylsulfonyl)-2 H -1,2,3-triazole.
- Authors
Salinas-Torres, Angélica; Portilla, Jaime; Rojas, Hugo; Becerra, Diana; Castillo, Juan-Carlos
- Abstract
The 1,2,3-Triazole derivatives containing the sulfonyl group have proved their biological importance in medicinal chemistry and drug design. In this sense, we describe the regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole 3 in good yield through a classical sulfonamidation reaction of 1H-1,2,3-triazole 1 with benzenesulfonyl chloride 2 in dichloromethane using a slight excess of triethylamine at 20 °C for 3 h. This procedure is distinguished by its short reaction time, high yield, excellent regioselectivity, clean reaction profile, and operational simplicity. The sulfonamide 3 was characterized by high-resolution mass spectrometry, FT–IR, UV–Vis, 1D and 2D NMR spectroscopy, and elemental analysis. The sulfonamide 3 exhibited moderate activity against UO-31 renal, SNB-75 central nervous system, HCT-116 colon, and BT-549 breast cancer cell lines, with growth inhibition percentages (GI%) ranging from 10.83% to 17.64%.
- Subjects
SULFONYL group; PHARMACEUTICAL chemistry; NUCLEAR magnetic resonance spectroscopy; CENTRAL nervous system; MASS spectrometry; SULFONYL compounds
- Publication
Molbank, 2022, Vol 2022, Issue 2, pM1387
- ISSN
1422-8599
- Publication type
Article
- DOI
10.3390/M1387