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- Title
PAIN REDUCTION AND FUNCTIONAL IMPROVEMENT IN KNEE OSTEOARTHRITIS: A CLINICAL COMPARISON OF NSAIDS AND OPIOIDS.
- Authors
Garg, Pooja; Aggarwal, Aditya
- Abstract
Background: Knee osteoarthritis (OA) is a significant contributor to pain and disability globally, with the efficacy and safety of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and opioids in managing this condition are still being debated. Objective: This study aimed to evaluate and compare the effects of NSAIDs and opioids on knee pain reduction and functional improvement in knee OA patients. Methods: A randomised controlled trial was conducted at the Orthopedics Department of Varun Arjun Medical College & Rohilkhand Hospital, involving 80 knee OA patients aged 40-60 years. Participants were randomly assigned to two groups: Group I (n=40) receiving NSAIDs and Group II (n=40) subjects receiving opioids Pain intensity was assessed using the Visual Analog Scale (VAS), and functional status was evaluated through the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline and bi-weekly intervals over three months. Adverse events were also monitored. Results: Both NSAIDs and opioids significantly alleviated pain and enhanced functional status over a 3-month period, evidenced by reductions in mean VAS scores by -2.2 for Group-I and -1.7 for Group-II; (P=0.001) and mean WOMAC scores -16.2 for NSAIDs and -12.2 for opioids; (P=0.001). NSAIDs exhibited marginally better efficacy and a more favourable side effect profile, although opioids were linked to a significantly higher incidence of constipation (P=0.02). Conclusion: NSAIDs and opioids effectively manage knee OA pain, with NSAIDs slightly outperforming opioids in effectiveness and safety. These results underscore the necessity of tailored pain management strategies for knee OA patients. Further studies must validate these findings over larger populations and extended periods.
- Subjects
KNEE pain; KNEE osteoarthritis; PAIN management; OPIOIDS; NONSTEROIDAL anti-inflammatory agents; ANTI-inflammatory agents
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 4, p1745
- ISSN
0975-3583
- Publication type
Article