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- Title
A Cross Sectional Study on Clinical Profile and Risk Factors of Stroke with Special Emphasis on Homocysteine Levels.
- Authors
V., Ranjith; K., Srinivas; P. V., Dinesh
- Abstract
BACKGROUND: Stroke is one of the leading causes of death and disability. It is now becoming an important cause of premature death and disability in a country like India. There are many risk factors for stroke which include age, smoking, alcohol consumption, physical inactivity, hypertension, dyslipedemia, diabetes mellitus, obesity, cardiovascular diseases and metabolic syndrome. Certain biochemical factors have also been implicated as a definite modifiable risk factor. OBJECTIVE: To describe the clinical profile of patients admitted with stroke and also to identify the risk factors of stroke with special emphasis on homocysteine levels. MATERIALS AND METHODS: A cross sectional study was conducted among 100 stroke patients admitted at a tertiary care teaching hospital in Mysore between April 2017 to March 2020. Permission from Institutional Ethics Committee was obtained before the start of the study. Blood was obtained from all patients and the results obtained were entered in the preformed performa along with other clinical parameters. RESULTS Most of the patients (41%) belonged to the age group of 60 to 79 years and were males (84%). 94% had infarct and 6% had cerebral haemorrhage. Proportion of patients who had hypertension, diabetes, were smokers, and consumed alcohol were 46%, 22%, 50% and 61% respectively. The mean serum homocysteine level was 18.19 ± 9.98. Serum cholesterol and serum homocysteine were significantly higher in the younger age group when compared to those in age group of more than 45 years. Patients without diabetes had high homocysteine levels when compared to diabetic patients. A negative relationship between age and homocysteine levels was seen. CONCLUSION: The incidence of stroke was highest in males belonging to the age group of 60 to 79 years with hemiplegia being the most common presentation and middle cerebral artery being the most common vascular territory involved. Higher serum triglycerides and homocysteine levels were significantly associated with young stroke. A negative correlation between diabetes, age and homocysteine levels was seen.
- Subjects
MYSURU (India); INDIA; DISEASE risk factors; HOMOCYSTEINE; CEREBRAL hemorrhage; BLOOD cholesterol; STROKE; HEMIPLEGIA; CARDIOVASCULAR diseases
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 1, p2354
- ISSN
0975-3583
- Publication type
Article