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- Title
AN ORIGINAL PAPER FROM THE ALIGARH MUSLIM UNIVERSITY REGARDING MICROVASCULAR DENSITY AND VASCULAR CHANGES IN ENDOMETRIAL SAMPLES IN DYSFUNCTIONAL UTERINE BLEEDING.
- Authors
John T., Vanesa; Afroz, Nishat; Khan, Nazoora
- Abstract
BACKGROUND Menorrhagia, a common gynaecological problem, accounts for up to 20% of outpatient clinic visits by women of reproductive age. Our intent was to study the various histopathological changes in dysfunctional uterine bleeding and the changes in blood vessels viz number morphology and finally to correlate with the clinical findings. METHODS About 200 patients were included in the three-year study, which was carried out in the Department of Pathology in conjunction with the Department of Obstetrics and Gynaecology. The study group consisted of individuals in the reproductive age group who did not use an oral contraceptive drug or an intrauterine device and who showed signs of irregular, intermittent, protracted, or heavy menstrual bleeding coagulation problem was excluded initially. Ethics committee clearance and consent from patients were taken as per protocol. RESULTS In this study the varying patterns observed were proliferative pattern, secretory pattern/therapy related changes, disordered proliferative endometrium endometrial hyperplasia and hyperplasia with atypia. The patterns which showed a significant change in the number and structure of blood vessels come under the proliferative pattern of endometrium viz disordered proliferation, endometrial hyperplasia and hyperplastic endometrium with atypia. All other patterns did not have a significant change in vasculature. CONCLUSION As a result, it was determined that abnormal vascular morphology in the various endometrial patterns mentioned above might be the pathogenic cause behind dysfunctional uterine haemorrhage abnormal endometrial angiogenesis and poor vascular maturation are linked to AUB. Our study and literature review validates the body of research showing that low levels of antiangiogenic factors and high levels of proangiogenic factors impede the maturation of vasculature, making them more brittle and permeable. This is consistent with our theory, and these pathways seem to be crucial to the pathophysiology of AUB. Examining the changes in angiogenesis in these individuals may reveal targets for AUB treatment.
- Subjects
ALIGARH Muslim University; METRORRHAGIA; UTERINE hemorrhage; MENORRHAGIA; CHILDBEARING age; INTRAUTERINE contraceptives; ENDOMETRIAL hyperplasia; LITERATURE reviews
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 1, p787
- ISSN
0975-3583
- Publication type
Article