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- Title
Biochemical and histological investigation of the effects of melatonin and vitamin C on damage to rat bulbus olfactory after chronic cellulose thinner inhalation.
- Authors
M., Önder; S., Gümüşlü; G. E., Genç; E. İ., Gürer; B. O., Yolcular; N., Oğuz
- Abstract
Objective: To investigate the effects of melatonin and vitamin C on the damage caused by rat bulbus olfactorius due to chronic inhalation of cellulosic thinner. Methods: Research ventilation was performed in special glass cages at constant temperature and pressure. In this study, 30 young male Wistar rats of the Rattus norvegicus species weighing approximately 400-450 g were used. The rats were divided into 3 groups. Groups; control group and thinner group and thinner, melatonin and vitamin C group. Ten rats were included in each group and were allowed to use thinner inhalation in air-caged glass cages for 1 hour at 1 hour twice daily for 6 weeks. At the end of the experiment, the animals were sacrificed and the tissue was analyzed. Results: At the end of the experiment, histology of bulbus olfactorius tissue: Hematoxylin-Eosin staining; control rooms bulbus olfactorius layers, Thinner inhaling group and Thinner +Melatonin+Cvitamin comparative layers were not analyzed Biochemical examination; Catalase Enzyme Activity, Glutathione Peroxidase Enzyme Activity, Superoxide Dismutase Activity were determined. Conclusion: After thinner inhalation, damage to the bulbus olfactorius occurred and biochemical and histological levels of melatonin and vitamin C were prevented.
- Subjects
RATS; VITAMIN C; RATTUS norvegicus; GLUTATHIONE peroxidase; CONTROL rooms; SUPEROXIDE dismutase
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue Supplement2, pS186
- ISSN
1307-8798
- Publication type
Article