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- Title
Phenotype Heterogeneity in Glucokinase--Maturity-Onset Diabetes of the Young (GCK-MODY) Patients.
- Authors
Wędrychowicz, Anna; Tobór, Ewa; Wilk, Magdalena; Ziółkowska-Ledwith, Ewa; Rams, Anna; Wzorek, Katarzyna; Sabal, Barbara; Stelmach, Małgorzata; Starzyk, Jerzy B.
- Abstract
Objective: The aim of the study was to evaluate the clinical phenotypes of glucokinase-maturity-onset diabetes of the young (GCKMODY) pediatric patients from Southwest Poland and to search for phenotype-genotype correlations. Methods: We conducted a retrospective analysis of data on 37 CGK-MODY patients consisting of 21 girls and 16 boys of ages 1.9-20.1 (mean 12.5±5.2) years, treated in our centre in the time period between 2002 and 2013. Results: GCK-MODY carriers were found in a frequency of 3% among 1043 diabetes mellitus (DM) patients and constituted the second most numerous group of DM patients, following type 1 DM, in our centre. The mean age of GCK-MODY diagnosis was 10.4±4.5 years. The findings leading to the diagnosis were impaired fasting glucose (IFG) (15/37), symptoms of hyperglycemia (4/37), and a GCK-MODY family history (18/37). Mean fasting blood glucose level was 6.67±1.64 mmol/L. In the sample, there were patients with normal values (4/37), those with DM (10/37), and IFG (23/37). In OGTT, 120 min glucose level was normal in 8, diabetic in 2, and characteristic for glucose intolerance in 27 of the 37 cases. Twelve of the 37 cases (32%) were identified as GCK-MODY carriers. In the total group, mean C-peptide level was 2.13±0.65 ng/mL and HbA1c was 6.26±0.45% (44.9±-18 mmol/mol). Thirty-two patients had a family history of DM. DM autoantibodies were detected in two patients. The most common mutations were p.Gly318Arg (11/37) and p.Val302Leu (8/37). There was no correlation between type of mutations and plasma glucose levels. Conclusion: The phenotype of GCK-MODY patients may vary from those characteristic for other DM types to an asymptomatic state with normal FG with no correlation with genotype.
- Subjects
POLAND; MATURITY onset diabetes of the young; BLOOD sugar analysis; GENETICS of type 2 diabetes; AUTOANTIBODIES; C-peptide; GLUCOSE tolerance tests; GLYCOSYLATED hemoglobin; HYPERGLYCEMIA; LONGITUDINAL method; GENETIC mutation; TYPE 2 diabetes; PROBABILITY theory; T-test (Statistics); TRANSFERASES; PHENOTYPES; RETROSPECTIVE studies; GLUCOSE intolerance; DATA analysis software; DESCRIPTIVE statistics; GENOTYPES; SYMPTOMS
- Publication
Journal of Clinical Research in Pediatric Endocrinology, 2017, Vol 9, Issue 3, p246
- ISSN
1308-5727
- Publication type
Article
- DOI
10.4274/jcrpe.4461