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- Title
Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones.
- Authors
Singh, Balwinder; Sharma, Vishal; Singh, Gagandeep; Kumar, Rakesh; Arora, Saroj; Ishar, Mohan Paul Singh
- Abstract
Novel substituted chromenopyridones (3a-j and 6a-d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.
- Subjects
ANTINEOPLASTIC agents; PYRIDONE; CANCER cells; CELL lines; SUBSTITUTION reactions
- Publication
International Journal of Medicinal Chemistry, 2013, p1
- ISSN
2090-2069
- Publication type
Article
- DOI
10.1155/2013/984329