We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease.
- Authors
Raygan, Fariba; Rezavandi, Zohreh; Bahmani, Fereshteh; Ostadmohammadi, Vahidreza; Mansournia, Mohammad Ali; Tajabadi-Ebrahimi, Maryam; Borzabadi, Shokoofeh; Asemi, Zatollah
- Abstract
Background: This study was conducted to evaluate the effects of probiotic supplementation on metabolic profiles in diabetic patients with coronary heart disease (CHD). Methods: This randomized, double-blind, placebo-controlled trial was performed among 60 diabetic patients with CHD, aged 40–85 years at a cardiology clinic in Kashan, Iran, from October 2017 through January 2018. Patients were randomly divided into two groups to take either probiotic supplements (n = 30) or placebo (n = 30) for 12 weeks. Fasting blood samples were taken at the beginning of the study and after the 12-week intervention to determine related markers. Results: After 12-week intervention, probiotic supplementation significantly decreased fasting plasma glucose (β − 20.02 mg/dL; 95% CI − 33.86, − 6.17; <italic>P </italic>= 0.005), insulin (β − 2.09 µIU/mL; 95% CI − 3.77, − 0.41; <italic>P </italic>= 0.01), insulin resistance (β − 0.50; 95% CI − 0.96, − 0.03; <italic>P </italic>= 0.03) and total-/HDL-cholesterol ratio (β − 0.27; 95% CI − 0.52, − 0.03; <italic>P </italic>= 0.02), and significantly increased insulin sensitivity (β 0.008; 95% CI 0.001, 0.01; <italic>P </italic>= 0.02) and HDL-cholesterol levels (β 2.52 mg/dL; 95% CI 0.04, 5.00; <italic>P </italic>= 0.04) compared with the placebo. Moreover, probiotic supplementation led to a significant reduction in serum high sensitivity C-reactive protein (β − 0.88 mg/L; 95% CI − 1.39, − 0.38; <italic>P </italic>= 0.001), and a significant elevation in total antioxidant capacity (β 108.44 mmol/L; 95% CI 47.61, 169.27; <italic>P </italic>= 0.001) and total glutathione levels (β 45.15 µmol/L; 95% CI 5.82, 84.47; <italic>P </italic>= 0.02) compared with the placebo. Probiotic supplementation did not affect other metabolic profiles. Conclusions: Overall, we found that probiotic supplementation for 12 weeks had beneficial effects on glycemic control, HDL-cholesterol, total-/HDL-cholesterol ratio, biomarkers of inflammation and oxidative stress in diabetic patients with CHD. <italic>Trial registration</italic> Clinical trial registration number <ext-link>http://www.irct.ir</ext-link>: IRCT2017082733941N5
- Subjects
TYPE 2 diabetes; PEOPLE with diabetes; CORONARY disease; PROBIOTICS; C-reactive protein
- Publication
Diabetology & Metabolic Syndrome, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1758-5996
- Publication type
Article
- DOI
10.1186/s13098-018-0353-2