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- Title
Silver Nanoparticles and Graphene Oxide Complex as an Anti-Inflammatory Biocompatible Liquid Nano-Dressing for Skin Infected with Staphylococcus aureus.
- Authors
Zielińska-Górska, Marlena; Sosnowska-Ławnicka, Malwina; Jaworski, Sławomir; Lange, Agata; Daniluk, Karolina; Nasiłowska, Barbara; Bartosewicz, Bartosz; Chwalibog, André; Sawosz, Ewa
- Abstract
Background: Bacterial skin infections, including Staphylococcus aureus, are a powerful and still not fully resolved problem. The aim of this research was to determine the possibility of using a complex of graphene oxide (GO) encrusted with silver nanoparticles as an effective antibacterial agent against S. aureus and to assess its pro-inflammatory properties.Methods: The tests were carried out in vitro on EpiDerm™ Skin, an artificial skin model (MatTek in vitro Life Science Laboratories, Slovak Republic), and the fibroblast cell line (HFF-2 from ATCC, USA). Both models were infected with S. aureus bacteria (ATCC 25923) and then treated with antibiotics or our experimental factors: silver nanoparticles (AgNPs, Nano-koloid, Poland), graphene oxide (GO, NanoPoz, Poland), and complex AgNP-GO (hydrocolloid created by self-assembly).Results: The antibacterial effectiveness of the AgNP-GO complex was equivalent to that of the antibiotic. In addition, an increase in the level of pro-inflammatory cytokines was observed under the influence of antibiotic administration, in contrast to the effect of AgNP-GO, which showed very limited pro-inflammatory activity.Conclusion: Hydrocolloid of the AgNP-GO complex, administered in the form of a liquid dressing, may act as an antibacterial agent and also reduce inflammation induced by S. aureus infection.
- Subjects
POLAND; SLOVAKIA; SILVER nanoparticles; GRAPHENE oxide; LIFE sciences; STAPHYLOCOCCUS aureus; ARTIFICIAL skin
- Publication
Journal of Inflammation Research, 2023, Vol 16, p5477
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S431565