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- Title
In vitro synergistic activity of lidocaine and miconazole against Candida albicans.
- Authors
Oliveira Cunha, Maria da Conceição dos Santos; de Almeida Filho, Tarcísio Paulo; Cunha, Francisco Afrânio; da Silva Farias, Ana Gesselena; de Souza, Ieda Pereira; Menezes, Everardo Albuquerque
- Abstract
Candida albicans is the main yeast isolated from vulvovaginal candidiasis(VVC) and a major antifungal used to treat VVC is miconazole (MZ), it shows local toxic effects, such as irritation and burns. The lidocaine (LD) is a local anesthetic. The aim of this study was to evaluate the synergistic activity of LD/MZ against 19 strains of C. albicans isolated from vaginal secretion. 78.9% of the strains were susceptible to the combination LD/MZ, demonstrating synergism of drugs. These drugs can be used to produce vaginal creams to treat VVC, especially drug resistant.
- Subjects
VULVOVAGINAL candidiasis; LIDOCAINE; MICONAZOLE; LOCAL anesthetics; CANDIDA albicans; IN vitro studies
- Publication
Acta Scientiarum: Health Sciences, 2017, Vol 39, Issue 2, p129
- ISSN
1679-9291
- Publication type
Article
- DOI
10.4025/actascihealthsci.v39i2.32413