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- Title
Vancomycin‐induced linear IgA bullous dermatosis presenting as generalized fixed drug eruption.
- Authors
Bakke, Joshua R.; Chantara, Alexandra; Cash, Joshua; Fisher, Kristopher R.
- Abstract
Vancomycin-induced linear IgA bullous dermatosis presenting as generalized fixed drug eruption The various cutaneous manifestations of intravenous (IV) vancomycin-induced eruptions including red man syndrome, drug-induced hypersensitivity syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, and linear immunoglobulin A (IgA) bullous dermatosis (LABD) have been well-described in the contemporary dermatologic literature.[[1]] Drug-induced LABD is most frequently attributed to vancomycin and distinguished by the presence of linear IgA deposition at the dermo-epidermal junction. Vancomycin is regarded as one of the most common causes of drug-induced LABD with perilesional biopsy specimens frequently demonstrating the characteristic linear IgA deposition on DIF.[8] In the vast majority of these cases indirect immunofluorescence remains negative.
- Subjects
EOSINOPHILIA; ANTIBODY-dependent cell cytotoxicity; DRUGS
- Publication
Journal of Cutaneous Pathology, 2019, Vol 46, Issue 12, p979
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.13563