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- Title
Examining the evidence for mutual modulation between m6A modification and circular RNAs: current knowledge and future prospects.
- Authors
Tang, Xiaozhu; Guo, Mengjie; Zhang, Yuanjiao; Lv, Junxian; Gu, Chunyan; Yang, Ye
- Abstract
The resistance of cancer cells to treatment significantly impedes the success of therapy, leading to the recurrence of various types of cancers. Understanding the specific mechanisms of therapy resistance may offer novel approaches for alleviating drug resistance in cancer. Recent research has shown a reciprocal relationship between circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification, and their interaction can affect the resistance and sensitivity of cancer therapy. This review aims to summarize the latest developments in the m6A modification of circRNAs and their importance in regulating therapy resistance in cancer. Furthermore, we explore their mutual interaction and exact mechanisms and provide insights into potential future approaches for reversing cancer resistance.
- Publication
Journal of Experimental & Clinical Cancer Research (17569966), 2024, Vol 43, Issue 1, p1
- ISSN
1756-9966
- Publication type
Article
- DOI
10.1186/s13046-024-03136-2