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- Title
Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome.
- Authors
Kumar, Radhika; Dohlman, Claes H.; Chodosh, James
- Abstract
Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure. Findings: Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction. Conclusion: Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela.
- Subjects
ACETAZOLAMIDE; STEVENS-Johnson Syndrome; SULFAMETHOXAZOLE; GLAUCOMA; VISION disorders; INTRAOCULAR pressure
- Publication
BMC Research Notes, 2012, Vol 5, Issue 1, p205
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/1756-0500-5-205