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- Title
Cardiovascular risk factors and characterization of retinal drusen by OCT in subjects with genetic risk for the development of Alzheimer disease.
- Authors
Salobrar‐Garcia, Elena; Sánchez‐Puebla, Lidia; Gil‐Salgado, Ines; Elvira‐Hurtado, Lorena; Fernández‐Albarral, José A.; Matamoros, Jose A.; RAMIREZ, Jose Manuel; Ramirez, Ana I.; Ramirez‐Toraño, Federico; Barabash, Ana; SALAZAR, Juan Jose; de Hoz, Rosa
- Abstract
Purpose: The aim of this work is analyse and characterize retinal drusen in cognitively healthy subjects at high risk of developing Alzheimer's disease (AD) (having a family history (FH+) of AD and carrying ɛ4 allele for the ApoE gene) compared to control subjects. Methods: Subjects are classified by their AD HF (HF‐ or HF+) and their ApoE ɛ4 allelic characterization (ApoE ɛ4‐ or ApoE ɛ4+) to analyse retinal drusen by OCT. Hypercholesterolemia (HCL), blood high pressure (HBP) and diabetes mellitus are also considered in this analysis. In addition, we analysed choroidal thickness by OCT. Results: When we compared the drusen number between groups taking account the HCL, there was statistical significance between the FH‐ ApoE ɛ4‐ HCL+ group and (i) FH+ ApoE ɛ4‐ HCL+ and (ii) FH+ ApoE ɛ4+ HCL‐ groups. Considering HBP and comparing the drusen number between the study groups, we found statistically significant differences when comparing the FH‐ ApoE ɛ4‐ HBP‐ group and the FH+ ApoE ɛ4+ HBP+ group. We also found statistically significant differences in the number of drusen when comparing the FH‐ ApoE ɛ4‐ HBP+ group with: (i) FH+ ApoE ɛ4‐ HBP‐ group; and (ii) FH+ ApoE ɛ4+ HBP+ group). Conclusions: In conclusion, there does not appear to be a relationship between AD HF or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared with patients without drusen, reaching statistical significance in the group of participants with an AD HF, without ApoE ɛ4, and with HCL. This thinning could trigger changes in choroidal perfusion that could give rise to the deposits that generate drusen.
- Subjects
CARDIOVASCULAR diseases risk factors; ALZHEIMER'S disease; DISEASE risk factors; CHOROID; AMYLOID plaque; CEREBRAL amyloid angiopathy; APOLIPOPROTEIN E4
- Publication
Acta Ophthalmologica (1755375X), 2022, Vol 100, pN.PAG
- ISSN
1755-375X
- Publication type
Abstract
- DOI
10.1111/j.1755-3768.2022.0790