We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Limonium Tetragonum Enhances Osteoblastogenesis while Suppressing the Adipocyte Differentiation.
- Authors
Jung-Ae Kim; Byul-Nim Ahn; Jung Hwan Oh; Fatih Karadeniz; Jung Im Lee; Youngwan Seo; Chang-Suk Kong
- Abstract
Halophytes are plants that live in harsh environments in coastal regions and are known for their diverse chemical compositions. Limonium tetragonum, a halophyte endemic to Korean shores, is known for its bioactive compounds and is utilized in folk medicine. In this study L. tetragonum extract (LHE) was used to determine and evaluate its anti-osteoporotic properties. Pre-adipocyte and pre-osteoblasts were induced to differentiate along with LHE treatment, and their differentiation was evaluated using differentiation markers. LHE treatment decreased lipid accumulation in 3T3-L1 preadipocytes during adipogenesis. Results indicated that the LHE treatment also decreased the levels of key adipogenic transcription factors: PPARγ, SREBP1c, and C/EBPα. Enhancing osteoblastogenesis by LHE treatment was confirmed in osteoblastogenesis-induced MC3T3-E1 pre-osteoblasts. Cells treated with LHE resulted in increased calcification and alkaline phosphatase (ALP) activity compared with osteoblasts without LHE treatment. Pro-osteogenic and antiadipogenic effects were also confirmed in D1 murine mesenchymal stromal cells which are capable of differentiation into both adipocytes and osteoblasts. LHE hindered adipogenesis and enhanced osteoblastogenesis in D1 MSCs in a similar fashion. In conclusion, L. tetragonum is believed to possess the potential to be utilized as a nutraceutical ingredient against osteoporotic conditions.
- Subjects
ADIPOGENESIS; FAT cells; STROMAL cells; ALKALINE phosphatase; TRADITIONAL medicine; TRANSCRIPTION factors
- Publication
Ocean & Polar Research, 2022, Vol 44, Issue 1, p29
- ISSN
1598-141X
- Publication type
Article
- DOI
10.4217/OPR.2022002