Acute Toxicity of Extract of Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) Seeds.

Saptarini, Nyi Mekar; Mustarichie, Resmi

Background: Extract of Sunan candlenut (Reutealis trisperma (Blanco) Airy Shaw) seed, the Euphorbiaceae family, has been shown to have anti-alopecia activity. Extract safety must be determined so that the extract can be developed into herbal preparations. Aim: The purpose of this study was to determine the acute toxicity and toxic symptoms of Sunan candlenut seed extract. Materials and Methods: Acute toxicity assay was conducted on female Swiss Webster mice with various concentrations of Sunan candlenut seed extract (70, 700, 1400, 3500, and 7000 mg/kg BW mice), then observed the toxic symptoms for 14 days. Results: The LD50 value of Sunan candlenut seed extract was 4954 mg/kg BW mice. This extract has a significant effect on the central nervous system by reducing the motoric activity (P = 2 × 10-4) and retablisment (P = 0.002), and the autonomic nervous system by disturbing ptosis (P = 0.032) and breathing (P = 0.001). Conclusion: The Sunan candlenut seed extract was 6th category, i.e., relatively harmless, based on the Hodge and Sterner toxicity scale.

CENTRAL nervous system; EXTRACTS; AUTONOMIC nervous system; BARK; EUPHORBIA

Drug Invention Today, 2020, Vol 14, Issue 5, p753

0975-7619

Academic Journal