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- Title
In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E<sub>2</sub> biosynthesisb.
- Authors
Landa, Premysl; Kokoska, Ladislav; Pribylova, Marie; Vanek, Tomas; Marsik, Petr
- Abstract
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E2 catalysed by COX-2 with an IC50 value of 0.8 μM what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 μM and 0.8 μM, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 μM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
- Publication
Archives of Pharmacal Research, 2009, Vol 32, Issue 1, p75
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-009-1120-6