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- Title
A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.
- Authors
Sjövall, Johanna; Wahlberg, Peter; Almquist, Helen; Kjellén, Elisabeth; Brun, Eva
- Abstract
ABSTRACT Background The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks after radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods One hundred five patients, mainly with oropharyngeal human papillomavirus (HPV)-positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post-RT. The PET results determined the management of the neck: observation versus neck dissection. Results Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2-year OS rate was 86.3%. Conclusion PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. © 2015 Wiley Periodicals © 2015 Wiley Periodicals, Inc. Head Neck 38: E473-E479, 2016
- Subjects
HEAD &; neck cancer treatment; CANCER treatment; SQUAMOUS cell carcinoma; POSITRON emission tomography; CANCER radiotherapy research; CANCER relapse
- Publication
Head & Neck, 2016, Vol 38, pE473
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24021