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- Title
Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: A retrospective review.
- Authors
Gray, Stacey T.; Herr, Marc W.; Sethi, Rosh K. V.; Diercks, Gillian; Lee, Linda; Curry, William; Chan, Annie; Clark, John; Holbrook, Eric H.; Rocco, James; Sadow, Peter M.; Lin, Derrick T.
- Abstract
ABSTRACT Background Sinonasal undifferentiated carcinoma (SNUC) is a high-grade, aggressive neoplasm. Low incidence and poor outcomes make identification of prognostic factors and treatment standardization difficult. Similarly, little is known regarding the association of human papillomavirus (HPV) with SNUC. Methods A retrospective review was conducted. Extracted information included treatment received, tumor recurrence, patient survival, p16 expression, and HPV status. The Kaplan-Meier method was used to estimate overall survival (OS) and disease-free survival (DFS). Survival trends were compared using the log-rank test. Results Nineteen patients received multimodality treatment for SNUC. Five-year OS and DFS rates were 45.2% and 50.7%, respectively, with no significant difference between treatment types. Tumors from 11 patients were p16-positive and 9 of these were also HPV-positive. Kaplan-Meier analysis demonstrated improved survival. Conclusion Our series demonstrates a higher prevalence of HPV in SNUC than previously reported. HPV-positive SNUCs may benefit from improved survival and should be investigated further in future studies. © 2014 Wiley Periodicals, Inc. Head Neck 37: 366-374, 2015
- Subjects
CARCINOMA; PARANASAL sinus cancer; NASAL tumors; PAPILLOMAVIRUS diseases; DISEASE prevalence; PROGNOSIS; TUMOR treatment; THERAPEUTICS
- Publication
Head & Neck, 2015, Vol 37, Issue 3, p366
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23606