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- Title
Some pyridazinone and phthalazinone derivatives and their vasodilator activities.
- Authors
Demirayak, Seref; Karaburun, Ahmet; Kayagil, Ismail; Erol, Kevser; Sirmagul, Basar
- Abstract
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2 H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2 H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2 H)-pyridazinone or 4-(4-aminophenyl)-1(2 H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4 H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.
- Publication
Archives of Pharmacal Research, 2004, Vol 27, Issue 1, p13
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02980038