We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases.
- Authors
Lee, Jang‐Jaer; Cheng, Shih‐Jung; Wang, Yi‐Ping; Jeng, Jiiang‐Huei; Chiang, Chun‐Pin; Kok, Sang‐Heng
- Abstract
Background Once-yearly zoledronic acid has been proven effective in the management of osteoporosis. Osteonecrosis of the jaws (ONJ) related to its use has not been reported since its approval in 2007. Methods Two women with osteoporosis/osteopenia developed ONJ after the second infusion of yearly zoledronic acid. They had no other systemic diseases and ONJ occurred after oral surgeries, which were performed about 2 months following drug administration. Results In 1 case osteonecrosis of the maxilla resolved after conservative therapy and sequestrectomy. In the other case bone necrosis developed on both sides of mandible, and the symptoms/signs of ONJ were partially responsive to conservative treatment. Conclusions ONJ related to yearly zoledronic acid is a severe complication that should not be ignored. To minimize the risk, we recommend preventive oral care before the start of therapy and avoiding dental invasive procedures within 3 months after drug administration. © 2011 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects
ZOLEDRONIC acid; OSTEOPOROSIS treatment; OSTEOPOROSIS prevention; JAW necrosis; OSTEONECROSIS; ORAL hygiene; PREVENTION
- Publication
Head & Neck, 2013, Vol 35, Issue 1, pE6
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21758