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- Title
Squamous epithelial changes of the larynx: Diagnosis and therapy.
- Authors
Ferlito, Alfio; Devaney, Kenneth O.; Woolgar, Julia A.; Slootweg, Pieter J.; Paleri, Vinidh; Takes, Robert P.; Strojan, Primož; Bradley, Patrick J.; Rinaldo, Alessandra; Eisele, David W.
- Abstract
It can be confusing for clinicians to work their way through the tangle of pathologic terms used in surgical pathology reports to describe squamous abnormalities in laryngeal biopsies. After a brief review of the normal microscopic anatomy of the larynx and time-honored clinical designations for surface-based abnormalities, this report sorts pathologic changes into 2 groups: those changes that do not carry a premalignant potential (including squamous metaplasia, squamous hyperplasia, pseudoepitheliomatous hyperplasia, keratosis, and parakeratosis) and those that do (including dyskeratosis, laryngeal intraepithelial neoplasia [LIN], atypia, dysplasia, and carcinoma in situ). Generally, lesions in the first group do not require additional therapy or close follow-up; lesions in the second group, however, demand either some form of local therapy or close follow-up to monitor for the development of a more aggressive pathology. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
- Subjects
LARYNGEAL cancer diagnosis; HISTOPATHOLOGY; PROGNOSIS; SURGICAL pathology; CARCINOMA; BIOPSY; HYPERPLASIA
- Publication
Head & Neck, 2012, Vol 34, Issue 12, p1810
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21862