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- Title
Synthesis and biological activity of 5-hydroxy-4-quinolones and 5-methoxy-4-quinolones as truncated acridones.
- Authors
Chun, Moon; Olmstead, Kay; Choi, Yongseok; Lee, Chong; Lee, Chong-Kyo; Kim, Joong; Lee, Jeewoo
- Abstract
A series of 5-hydroxy-4-quinolone ( 3) and 5-methoxy-4-quinolone ( 4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor, antiherpes and antituberculosis activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50=17.7 μM for HL60) which was greater than that of acronycine. However, these compounds didn't show any significant antiherpes or antituberculosis activity.
- Publication
Archives of Pharmacal Research, 1998, Vol 21, Issue 4, p445
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02974641