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- Title
An unexpected role of plasminogen activator inhibitor-type 1 (PAI-1) in renal fibrosis.
- Authors
Yufeng Huang; Noble, Nancy
- Abstract
The article examines the role of plasminogen activator inhibitor-type 1 (PAI-1) in renal fibrosis. It has been thought that the profibrotic actions of PAI-1 are based on inhibition of plasmin generation, which results in decreased turnover of pathologic matrix. PAI-1 may be profibrotic by enhancing recruitment of fibrosisinducing cells independent of its effect to decrease matrix turnover. These plasmin-independent functions of PAI-1 may involve PAI-1 binding to vitronectin, or PAI-1 interference with cell migration or cell binding to matrix.
- Subjects
PLASMINOGEN activators; FIBROSIS; KIDNEY diseases; PLASMIN; VITRONECTIN; CELL migration; PROTEIN metabolism; SEQUENCE analysis; MICROBIOLOGICAL assay; MACROPHAGES; FIBRINOLYSIS; GENE expression; BLOOD coagulation factors
- Publication
Kidney International, 2005, Vol 67, Issue 6, p2502
- ISSN
0085-2538
- Publication type
Editorial
- DOI
10.1111/j.1523-1755.2005.00368.x