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- Title
Long‐term outcomes of high dose carbon‐ion radiation therapy for unresectable upper cervical (C1‐2) chordoma.
- Authors
Aoki, Shuri; Koto, Masashi; Ikawa, Hiroaki; Imai, Reiko; Tokuhiko, Omatsu; Shinoto, Makoto; Takiyama, Hirotoshi; Yamada, Shigeru; Tsuji, Hiroshi
- Abstract
Background: Chordoma is a rare, locally invasive neoplasm of the axial skeleton. Complete resection is often difficult, especially for the upper‐cervical (C1‐2) spine. We evaluated the efficacy and safety of carbon‐ion radiotherapy (CIRT) for unresectable C1‐2 chordoma. Methods: Patients with C1‐2 chordoma treated with definitive CIRT (60.8 Gy [RBE] in 16 fractions) were retrospectively analyzed. We evaluated OS, LC, PFS, and toxicity. Results: Nineteen eligible patients all completed the planned course of CIRT. With the median follow‐up 68 months (range: 29–144), median OS was 126 months (range: 36‐NA). Five‐year OS, LC, and PFS were 68.4% (95% CI, 42.8%–84.4%), 75.2% (46.1%–90.0%), and 64.1% (36.3%–82.3%), respectively. Regarding acute toxicity of grade ≥3, there was only one grade 3 mucositis. Late toxicity included radiation‐induced myelitis (grade 3 in 1 patient; 5.3%), and compression fractures (n = 5; 26.3%). Conclusions: High‐dose CIRT is a promising treatment option for unresectable upper cervical chordoma.
- Subjects
CHORDOMA; RADIOTHERAPY; RADIATION doses; COMPRESSION fractures; VERTEBRAL fractures; RADIOTHERAPY safety
- Publication
Head & Neck, 2022, Vol 44, Issue 10, p2162
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27127