We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intraoperative hypertensive crisis due to a catecholamine-secreting esthesioneuroblastoma.
- Authors
Salmasi, Vafi; Schiavi, Adam; Binder, Zev A.; Ruzevick, Jacob; Orr, Brent A.; Burger, Peter C.; Ball, Douglas W.; Blitz, Ari M.; Koch, Wayne M.; Ishii, Masaru; Gallia, Gary L.; Andersen, Peter
- Abstract
ABSTRACT Background Although uncommon, esthesioneuroblastomas may produce clinically significant amounts of catecholamines. Methods We report a patient with a catecholamine-secreting esthesioneuroblastoma who developed an intraoperative hypertensive crisis. Results A patient with a history of hypertension was referred to our skull base center for management of a residual esthesioneuroblastoma. A staged endonasal endoscopic approach was planned. At the conclusion of the first stage, a hypertensive crisis occurred. Workup revealed elevated levels of serum and urinary catecholamines. The patient was treated with alpha adrenoceptor blockade before the second stage. Serum catecholamine levels after this second stage were normal. On immunohistochemical analysis, the tumor cells were found to be positive for tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis, and achaete-scute homologue 1, a transcription factor essential in the development of olfactory and sympathetic neurons. Conclusion Catecholamine production should be considered in the differential of unexpected extreme hypertension during surgical resection of esthesioneuroblastoma. © 2015 Wiley Periodicals, Inc. Head Neck 37: E74-E80, 2015
- Subjects
CATECHOLAMINES; IMMUNOHISTOCHEMISTRY; TYROSINE hydroxylase; TRANSCRIPTION factors; SURGICAL complications
- Publication
Head & Neck, 2015, Vol 37, Issue 6, pE74
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23907