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- Title
Parotid metastatic disease from cutaneous squamous cell carcinoma: Prognostic role of facial nerve sacrifice, lateral temporal bone resection, immune status and P-stage.
- Authors
Shao, Angus; Wong, Danny K. C.; McIvor, Nicholas P.; Mylnarek, Alex M.; Chaplin, John M.; Izzard, Mark E.; Patel, Rajan S.; Morton, Randall P.
- Abstract
Background Recognized prognostic indicators for metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck include facial nerve involvement, immune status, and 'parotid' staging system (P-stage). We sought to examine the impact of lateral temporal bone resection (LTBR) on prognosis. Methods We conducted a retrospective analysis of 160 patients with metastatic cutaneous SCC to the parotid. All patients had parotidectomy and neck dissection; 27% had additional LTBR when the tumor was adherent to the temporal bone. Results Overall 5-year survival was 48%, disease-specific survival 77%, and locoregional control 83%. Corresponding results for immunocompetent versus immunocompromised were 55%, 86%, and 87% versus 12%, 48%, and 64%. On Cox regression analysis, only immunocompromised status (ie, lymphoproliferative disorder, organ-transplant patient) was prognostically significant ( p < .001). Conclusion More radical resection that may include LTBR mitigates the poorer prognosis with advanced disease in our series. Treatment must be individualized in immunocompromised patients who have shortened overall survival. © 2013 Wiley Periodicals, Inc. Head Neck 36: 545-550, 2014
- Subjects
CANCER patients; TEMPORAL bone; SQUAMOUS cell carcinoma; FACIAL nerve; CELL proliferation
- Publication
Head & Neck, 2014, Vol 36, Issue 4, p545
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23323