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- Title
Impact of p16, p53, smoking, and alcohol on survival in patients with oropharyngeal squamous cell carcinoma treated with primary intensity-modulated chemoradiation.
- Authors
Broglie, Martina A.; Soltermann, Alex; Rohrbach, David; Haile, Sarah R.; Pawlita, Michael; Studer, Gabriela; Huber, Gerard F.; Moch, Holger; Stoeckli, Sandro J.
- Abstract
Background Analysis of the impact of risk factors on survival in patients with oropharyngeal squamous cell carcinoma (OPSCC) treated by primary intensity-modulated radiotherapy (IMRT). Methods One hundred forty patients were included with tissue microarray (TMA) construction and immunohistochemical analysis in 124 patients (87%). Results Survival analysis of patients classified into 3 risk categories according to an algorithm based on p16, smoking, T classification, and N classification revealed significant differences with a low, intermediate, and high-risk group. There was a significant impact of p53 expression as surrogate marker for smoking on outcome. In multivariate analysis, p16-positivity was a positive predictor and alcohol as well as N classification was a negative predictor for survival. The algorithm was modified based on alcohol instead of smoking with even more significant differences between the groups. Conclusions A risk model based on multiple factors instead of p16 as single marker can define different risk groups to select patients for treatment deintensification in future prospective clinical trials. © 2013 Wiley Periodicals, Inc. Head Neck 35: 1698-1706, 2013
- Subjects
OROPHARYNGEAL cancer; SQUAMOUS cell carcinoma; IMMUNOHISTOCHEMISTRY; RADIOTHERAPY; XEROSTOMIA
- Publication
Head & Neck, 2013, Vol 35, Issue 12, p1698
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23231