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- Title
Effects of Milkfat on the Gut Microbiome of Patients After Bariatric Surgery, a Pilot Study.
- Authors
O'Neill, Liam; Pandya, Vidish; Grigoryan, Zoya; Patel, Rohit; DeSipio, Joshua; Judge, Thomas; Phadtare, Sangita
- Abstract
Background: The efficacy of bariatric surgery may be in part attributed to altered metabolism via new gut microbiome. Milkfat may promote the growth of microbes that are beneficial in long-term weight loss. Understanding the specific gut microbiome changes after surgery and their relationship to milkfat consumption may yield important strategies for managing obesity after bariatric procedures. Methods: In this pilot study, stool samples were collected from nine patients before and at the time of surgery, and at 1, 3, and 6 months post-surgery. At each time-point, dairy consumption was determined from dietary surveys. 16 s rRNA gene sequencing was performed followed by alpha diversity analysis. Comparisons of relative abundances of microbial taxa and analyses of fatty acids changes were performed. Results: Bariatric surgery led to enrichment of (i) Roseburia, associated with weight loss and (ii) Christensenellaceae, inversely related to body mass index. High milk-fat consumption correlated with enrichment of Blautia, inversely associated with visceral fat accumulation. Faecalibacterium, possibly associated with obesity, increased in patients with low milk-fat consumption. Butter was associated with decreased alpha diversity in all subjects (p-value = 0.038) and the frequency of its use was associated with decreased alpha diversity in patients (correlation = − 0.68, p-value = 0.042). Low-milk-fat consumers showed higher concentration of saturated fatty acids. Conclusions: Our results suggest that incorporating dairy products in post-bariatric-surgery dietary plans may help cultivate a gut microbiome that is effective in regulating fat storage as well as digesting beneficial metabolites. These observations will be helpful for the management of obesity in general population as well.
- Subjects
GUT microbiome; MILKFAT; BARIATRIC surgery; SATURATED fatty acids; FATTY acid analysis; GASTRIC bypass
- Publication
Obesity Surgery, 2022, Vol 32, Issue 2, p480
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-021-05805-z