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- Title
Gastric Bypass Compared with Sleeve Gastrectomy for Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis.
- Authors
de Brito e Silva, Miller Barreto; Tustumi, Francisco; de Miranda Neto, Antonio Afonso; Dantas, Anna Carolina Batista; Santo, Marco Aurélio; Cecconello, Ivan
- Abstract
The effects of bariatric procedures on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain unclear. A systematic review and meta-analysis was performed to compare the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on NAFLD/NASH. Patients submitted to RYGB presented significant reduction of steatohepatitis (RD: 0.53; 95% CI 0.33 to 0.74) and fibrosis (RD: 0.26; 95% CI 0.14 to 0.37). SG caused a significant reduction of steatohepatitis (RD: 0.42; 95% CI 0.27 to 0.57), but not of fibrosis (RD: 0.20; 95% CI −0.00 to 0.39). The NAFLD Activity Score was significantly improved after both procedures, as well as biochemical tests. No difference was found between RYGB and SG regarding the histopathological outcomes. SG and RYGB are equivalently effective for treating NAFLD/NASH.
- Subjects
FATTY liver; GASTRIC bypass; SLEEVE gastrectomy
- Publication
Obesity Surgery, 2021, Vol 31, Issue 6, p2762
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-021-05412-y