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- Title
Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors.
- Authors
Osorio, Giovana; Zulueta-Dorado, Teresa; González-Rodríguez, Patricia; Bernabéu-Wittel, José; Conejo-Mir, Julian; Ramírez-Lorca, Reposo; Echevarría, Miriam
- Abstract
<bold>Objectives: </bold>Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer.<bold>Methods: </bold>Analysis of AQP1 and AQP3 expression by immunohistochemistry of 72 skin biopsy specimens from melanocytic skin tumors, nonmelanocytic tumors, or healthy samples.<bold>Results: </bold>AQP1 showed strong labeling in 100% of benign common melanocytic nevi. Small blood vessels, stroma, and melanophages surrounding different types of melanomas tumors also were positive. Tumoral melanocytes in atypical nevi and melanomas were negative for AQP1. AQP3 showed strong labeling in 100% of melanocytic nevi, 100% of atypical melanocytic nevi, and 100% of melanomas. In all basal cell carcinomas and squamous cell carcinomas, staining for AQP3 was positive.<bold>Conclusions: </bold>To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets.
- Subjects
SKIN tumors; MELANOMA; BASAL cell carcinoma; SQUAMOUS cell carcinoma; SKIN cancer; BLOOD vessels; OROPHARYNX
- Publication
American Journal of Clinical Pathology, 2019, Vol 152, Issue 4, p446
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqz066