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- Title
Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma.
- Authors
Geyer, Julia T; Yigit, Nuri; Miyaguchi, Ayako; Cheng, Shuhua; Casano, Joseph; Mathew, Susan; Desai, Pinkal; Gergis, Usama; Tam, Wayne
- Abstract
<bold>Objectives: </bold>Rare cases of clonally related histiocytic sarcoma (HS) following B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) have been reported to date.<bold>Methods: </bold>We present a patient with HS, which appeared as a breast mass 12 months after the initial diagnosis of B-ALL.<bold>Results: </bold>Both HS and the B-ALL shared IGH-MYC and IGK gene rearrangements. Next-generation sequencing and whole-exome sequencing (WES) studies detected 35 common mutations, as well as mutations unique to B-ALL (16) and HS (15), including BRAF D594G. The patient achieved complete remission of B-ALL, but HS failed to respond to many cycles of intensive chemotherapy regimens. A partial response was achieved with sorafenib, a BRAF-targeted therapy.<bold>Conclusions: </bold>To our knowledge, this is the first study to demonstrate by WES that clonally related B-ALL and HS arise through divergent evolution from a common precursor. We present our findings together with a discussion of the previously reported cases of HS in patients with B-ALL.
- Subjects
RETICULUM cell sarcoma; LEUKEMIA; GENE rearrangement; LYMPHOMAS; BURKITT'S lymphoma
- Publication
American Journal of Clinical Pathology, 2019, Vol 152, Issue 4, p486
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1093/ajcp/aqz056