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- Title
Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy.
- Authors
Barakat, Fareed H.; Medeiros, L. Jeffrey; Wei, Eric X.; Konoplev, Sergej; Pei Lin; Jorgensen, Jeffrey L.; Lin, Pei
- Abstract
Waldenström macroglobulinemia (WM) is currently defined as lymphoplasmacytic lymphoma involving bone marrow (BM) associated with a serum IgM paraprotein. WM is typically composed of small lymphocytes, plasmacytoid lymphocytes, and plasma cells in variable proportions, which can change after therapy. In this study, we assessed 41 WM cases that required chemotherapy, 39 showing persistent disease in restaging BM specimens. In 10 cases, there was persistent monotypic plasmacytosis in BM in the absence of demonstrable monotypic B cells. The monotypic plasma cells represented 0.5% to 46% of the cellularity and persisted 1 to 50 months after the last course of chemotherapy. The plasma cells were best quantified by immunohistochemical analysis on paraffin sections. We conclude that WM can persist as a pure plasma cell population after therapy. This finding has implications for the immunophenotypic assessment of WM after therapy and may explain persistent IgM paraproteinemia in patients with WM with no evidence of a clonal B-lymphocyte population.
- Subjects
WALDENSTROM'S macroglobulinemia; BONE marrow; IMMUNOGLOBULIN M; PLASMA cells; IMMUNOHISTOCHEMISTRY; PARAPROTEINEMIA; ANTINEOPLASTIC agents; IMMUNOLOGICAL adjuvants; LYMPHOCYTE metabolism; THERAPEUTIC use of monoclonal antibodies; CARCINOGENESIS; B cells; CHROMOSOME banding; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; LYMPHOCYTES; LYMPHOPROLIFERATIVE disorders; RESEARCH funding; CYTOMETRY; THERAPEUTICS
- Publication
American Journal of Clinical Pathology, 2011, Vol 135, Issue 3, p365
- ISSN
0002-9173
- Publication type
journal article
- DOI
10.1309/AJCP15YFULCZHZVH