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- Title
The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non‐anesthetized sheep.
- Authors
Jufar, Alemayehu H.; Evans, Roger G.; May, Clive N.; Hood, Sally G.; Betrie, Ashenafi H.; Trask‐Marino, Anton; Bellomo, Rinaldo; Lankadeva, Yugeesh R.
- Abstract
Aim: Recruitment of renal functional reserve (RFR) with amino acid loading increases renal blood flow and glomerular filtration rate. However, its effects on renal cortical and medullary oxygenation have not been determined. Accordingly, we tested the effects of recruitment of RFR on renal cortical and medullary oxygenation in non‐anesthetized sheep. Methods: Under general anesthesia, we instrumented 10 sheep to enable subsequent continuous measurements of systemic and renal hemodynamics, renal oxygen delivery and consumption, and cortical and medullary tissue oxygen tension (PO2). We then measured the effects of recruitment of RFR with an intravenous infusion of 500 ml of a clinically used amino acid solution (10% Synthamin® 17) in the non‐anesthetized state. Results: Compared with baseline, Synthamin® 17 infusion significantly increased renal oxygen delivery mean ± SD maximum increase: (from 0.79 ± 0.17 to 1.06 ± 0.16 ml/kg/min, p < 0.001), renal oxygen consumption (from 0.08 ± 0.01 to 0.15 ± 0.02 ml/kg/min, p < 0.001), and glomerular filtration rate (+45.2 ± 2.7%, p < 0.001). Renal cortical tissue PO2 increased by a maximum of 26.4 ± 1.1% (p = 0.001) and medullary tissue PO2 increased by a maximum of 23.9 ± 2.8% (p = 0. 001). Conclusions: In non‐anesthetized healthy sheep, recruitment of RFR improved renal cortical and medullary oxygenation. These observations might have implications for the use of recruitment of RFR for diagnostic and therapeutic purposes.
- Subjects
OXYGEN in the blood; GLOMERULAR filtration rate; SHEEP; OXYGEN consumption; BLOOD flow
- Publication
Acta Physiologica, 2023, Vol 237, Issue 4, p1
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/apha.13919