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- Title
Comparing Symptomatic and Asymptomatic Carotid Artery Atherosclerosis in Patients With Bilateral Carotid Vulnerable Plaques Using Magnetic Resonance Imaging.
- Authors
Xin, Ruijing; Yang, Dandan; Xu, Huimin; Han, Hualu; Li, Jin; Miao, Yingyu; Du, Ziwei; Ding, Qian; Deng, Shasha; Ning, Zihan; Shen, Rui; Li, Rui; Li, Cheng; Yuan, Chun; Zhao, Xihai
- Abstract
We compared plaque characteristics between symptomatic and asymptomatic sides in patients with bilateral carotid vulnerable plaques using magnetic resonance imaging (MRI). Participants (n = 67; mean age: 65.8 ± 7.7 years, 61 males) with bilateral carotid vulnerable plaques were included. Vulnerable plaques were characterized by intraplaque hemorrhage (IPH), large lipid-rich necrotic core (LRNC), or fibrous cap rupture (FCR) on MRI. Symptomatic vulnerable plaques showed greater plaque burden, LRNC volume (median: 221.4 vs 134.8 mm3, P =.003), IPH volume (median: 32.2 vs 22.5 mm3, P =.030), maximum percentage (Max%) LRNC (median: 51.3% vs 41.8%, P =.002), Max%IPH (median: 13.4% vs 9.5%, P =.022), cumulative slices of LRNC (median: 10 vs 8, P =.005), and more juxtaluminal IPH and/or thrombus (29.9% vs 6.0%, P =.001) and FCR (37.3% vs 16.4%, P =.007) than asymptomatic ones. After adjusting for plaque burden, differences in juxtaluminal IPH and/or thrombus (odds ratio [OR]: 5.49, 95% CI: 1.61-18.75, P =.007) and FCR (OR: 2.90, 95% CI: 1.16-7.24, P =.022) between bilateral sides remained statistically significant. For patients with bilateral carotid vulnerable plaques, symptomatic plaques had greater burden, more juxtaluminal IPH and/or thrombus, and FCR compared with asymptomatic ones. The differences in juxtaluminal IPH and/or thrombus and FCR between bilateral sides were independent of plaque burden.
- Subjects
CEREBROVASCULAR disease risk factors; THROMBOSIS; CAROTID artery diseases; CONFIDENCE intervals; CAROTID artery stenosis; MAGNETIC resonance imaging; ATHEROSCLEROSIS; RISK assessment; COMPARATIVE studies; DESCRIPTIVE statistics; ODDS ratio; HEMORRHAGE
- Publication
Angiology, 2022, Vol 73, Issue 2, p104
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/00033197211012531