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- Title
Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study.
- Authors
Júnior, Edmar Maciel Lima; Filho, Manoel Odorico de Moraes; Forte, Antonio Jorge; Costa, Bruno Almeida; Fechine, Francisco Vagnaldo; Alves, Ana Paula Negreiros Nunes; Moraes, Maria Elisabete Amaral de; Rocha, Marina Becker Sales; Júnior, Francisco Raimundo Silva; Soares, Maria Flaviane Araújo do Nascimento; Bezerra, Alane Nogueira; Martins, Camila Barroso; Mathor, Mônica Beatriz; Lima Júnior, Edmar Maciel; Moraes Filho, Manoel Odorico de; Silva Júnior, Francisco Raimundo
- Abstract
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial "partial-thickness" burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.
- Subjects
FORTALEZA (Brazil); BRAZIL; PEDIATRIC therapy; TILAPIA; MEDICAL personnel; NILE tilapia; PILOT projects; WOUND healing; SKIN grafting; XENOGRAFTS; BURNS &; scalds; SILVER sulfadiazine; RANDOMIZED controlled trials; FISHES; STATISTICAL sampling
- Publication
Journal of Burn Care & Research, 2020, Vol 41, Issue 2, p241
- ISSN
1559-047X
- Publication type
journal article
- DOI
10.1093/jbcr/irz149