We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.
- Authors
Merschjohann, Karin; Steverding, Dietmar
- Abstract
African trypanosomes exert significant morbidity and mortality in man and livestock. Only a few drugs are available for the treatment of trypanosome infections and therefore, the development of new anti-trypanosomal agents is required. Previously it has been shown that bloodstream-form trypanosomes are sensitive to the iron chelator deferoxamine. In this study the effect of 13 iron chelators on the growth of Trypanosoma brucei, T. congolense and human HL-60 cells was tested in vitro. With the exception of 2 compounds, all chelators exhibited anti-trypanosomal activities, with 50% inhibitory concentration (IC50) values ranging between 2.1 – 220 μM. However, the iron chelators also displayed cytotoxicity towards human HL-60 cells and therefore, only less favourable selectivity indices compared to commercially available drugs. Interfering with iron metabolism may be a new strategy in the treatment of trypanosome infections. More specifically, lipophilic ironchelating agents may serve as lead compounds for novel anti-trypanosomal drug development.
- Subjects
TRYPANOSOMA brucei; IRON chelates; MORTALITY; DISEASES; IRON metabolism; CLINICAL trials
- Publication
Kinetoplastid Biology & Disease, 2006, Vol 5, p1
- ISSN
1475-9292
- Publication type
Article
- DOI
10.1186/1475-9292-5-3