We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Demographic, clinical, and pathological features of early onset pancreatic cancer patients.
- Authors
Ntala, Chara; Debernardi, Silvana; Feakins, Roger M.; Crnogorac-Jurcevic, Tatjana
- Abstract
<bold>Background: </bold>Early onset pancreatic cancer (EOPC), i.e. pancreatic ductal adenocarcinoma (PDAC) occurring in patients below 50 years of age, is rare and there is limited information regarding risk factors, molecular basis and outcome. This study aimed to determine the demographic and clinicopathological features and survival figures for EOPC.<bold>Methods: </bold>A retrospective analysis of patients treated at the Royal London Hospital for PDAC between September 2004 and September 2015 was performed. Data on demographics, risk factors, presentation, pathological features, treatment and survival outcome were compared in EOPC and older PDAC patients.<bold>Results: </bold>Of 369 PDAC cases identified, 35 (9.5%) were EOPC. Compared to older patients, EOPC patients were more frequently male (71% vs 54%, p = 0.043) and less commonly of British origin (37% vs 70%, p = 0.002). There was no significant difference regarding the prevalence of any of the risk factors known to be associated with older PDAC patients. Fewer EOPC patients presented with resectable disease (23% vs 44%, p = 0.015) and more received adjuvant chemo/radiotherapy (60% vs 46%, p = 0.008). The overall median survival and stage specific survival did not differ significantly between the two groups, although a longer survival for localized disease was seen in EOPC patients (25 months (12.9-37, 95%CI) vs 13 months (10.5-15.5 95%CI) for older PDAC patients).<bold>Conclusions: </bold>The EOPC patients had different demographics and were more likely than their older PDAC counterparts to be male. Typically they presented with more advanced disease, received more aggressive treatment, and had on overall similar survival outcome.
- Subjects
RISK factors of pancreatic cancer; DUCTAL carcinoma; PANCREATIC cancer treatment; ADJUVANT treatment of cancer; SURVIVAL analysis (Biometry); PHYSIOLOGICAL effects of tobacco; DEMOGRAPHIC characteristics; CANCER risk factors
- Publication
BMC Gastroenterology, 2018, Vol 18, Issue 1, pN.PAG
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-018-0866-z