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- Title
Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease.
- Authors
Kiyama, Kazuhiro; Yoshifuji, Hajime; Kandou, Tsugumitsu; Hosono, Yuji; Kitagori, Koji; Nakashima, Ran; Imura, Yoshitaka; Yukawa, Naoichiro; Ohmura, Koichiro; Fujii, Takao; Kawabata, Daisuke; Mimori, Tsuneyo
- Abstract
<bold>Background: </bold>Immunoglobulin (Ig) G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and infiltration of IgG4(+) plasma cells into multiple organs. It is not known whether serum IgG4 is autoreactive in IgG4-RD. <bold>Methods: </bold>We measured anti-nuclear antibody (ANA) in 19 IgG4-RD cases, determined IgG subclasses of the ANA, and compared them with those of other systemic autoimmune diseases (systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, and polymyositis), using subclass-based ANA test (indirect immunofluorescence). <bold>Results: </bold>58 % of IgG4-RD cases were ANA-positive (cut-off: 1:40). Whereas their subclass of ANA was predominantly IgG2, we observed no IgG4-type ANA. In systemic autoimmune diseases, subclasses of ANA were mostly IgG1, 2, or 3, but IgG4-type ANA was very rarely detected. We also found several patients in whose serum ANA patterns differed among IgG subclasses, probably due to the difference of corresponding autoantigens. <bold>Conclusions: </bold>Although IgG4 is highly elevated in sera of IgG4-RD patients, their ANA do not include IgG4 subclass. These results offer new insight into the role of IgG4 and the pathogenesis of IgG4-RD, implying that each IgG subclass tends to cover its own spectrum of antigens, and IgG4 is not preferentially used to make ANA.
- Publication
BMC Musculoskeletal Disorders, 2015, Vol 16, Issue 1, p129
- ISSN
1471-2474
- Publication type
journal article
- DOI
10.1186/s12891-015-0584-4