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- Title
Electrochemical determination of thiethylperazine using semi-graphitized carbon nanofibers-MnO nanocomposite.
- Authors
Smajdor, Joanna; Zambrzycki, Marcel; Marzec, Mateusz; Paczosa-Bator, Beata; Piech, Robert
- Abstract
A new voltammetric method is proposed for high sensitive thiethylperazine (THP) determination, using a glassy carbon electrode modified with semi-graphitized carbon nanofibers/MnO nanocomposite (eCNF/MnO/GC). To the best of our knowledge, this is the first electrochemical assay of THP determination, and the first use of the eCNF/MnO as the electrode modifier. The proposed method using eCNF/MnO/GC is characterized by high repeatability and sensitivity of measurements, with the linearity of THP in the range from 0.05 to 2.2 µmol L−1. The lowest detection limit achieved on the eCNF/MnO/GC electrode for 30 s of preconcentration was 6.3 nmol L−1 THP in 0.05 mol L−1 acetate buffer of pH 5.6. The proposed method was successfully applied to highly sensitive THP determination in complex matrices, such as tablets and plasma with good recovery (98–103%). The RSD value obtained for THP measurement at a concentration of 0.1 µmol L−1 was 1.3%. Amperometric measurements of THP under the flow injection conditions were also performed to indicate the possibility of its fast and accurate determination (103% and 95% for unmodified and modified electrode, respectively), with the duration of single analysis of approx. 30 s.
- Subjects
CARBON nanofibers; CARBON electrodes; NANOCOMPOSITE materials; COMPLEX matrices; DETECTION limit; FLOW injection analysis; CARBON
- Publication
Microchimica Acta, 2023, Vol 190, Issue 11, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-023-06025-1