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- Title
Isolated and Sporadic Human Mesiodens Is Associated with a Synonymous Variant in the ACVR2A Gene.
- Authors
Chan-Woo Jo; Ji Hyun Lee; Je Seon Song; Min Kyoung Park; Sung-Won Cho; Jae-Hoon Lee; Hyo-Seol Lee
- Abstract
Purpose: The purpose of this study was to use targeted next-generation sequencing (NGS) to identify possible causative genes for isolated and sporadic human mesiodens. Methods: The targeted panel consisted of 101 target genes related to tooth development. NGS of this panel was initially performed on a discovery set (39 cases and 27 controls); association tests were performed after genotyping of nine selected variants in a validation set (57 cases and 56 controls). Results: Among these nine variants, a synonymous variant, ACVR2A (rs1128919) associated with mesiodens was identified. Moreover, in silico analysis was performed and demonstrated the instability of mRNA with the G allele. Conclusions: The formation of isolated and sporadic human mesiodens is associated with a synonymous variation in ACVR2A (rs1128919).
- Subjects
MESIODENS; GENETIC mutation; GENOTYPES; ALLELES; GENE expression; SUPERNUMERARY teeth
- Publication
Pediatric Dentistry, 2021, Vol 43, Issue 1, p39
- ISSN
0164-1263
- Publication type
Article