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- Title
Metabolizable Bi<sub>2</sub>Se<sub>3</sub> Nanoplates: Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging.
- Authors
Zhang, Xiao‐Dong; Chen, Jie; Min, Yuho; Park, Gyeong Bae; Shen, Xiu; Song, Sha‐Sha; Sun, Yuan‐Ming; Wang, Hao; Long, Wei; Xie, Jianping; Gao, Kai; Zhang, Lianfeng; Fan, Saijun; Fan, Feiyue; Jeong, Unyong
- Abstract
Bi, a high atomic number element, has a high photoelectric absorption coefficient, and Se has anticancer activity. Hence, their compound chalcogenide (Bi2Se3) deserves a thorough investigation for biomedical applications. This study reveals that Bi2Se3 nanoplates (54 nm wide) protected with poly(vinylpyrollidone) (PVP) could be presumed to have low toxicity even at a high dose of 20 mg/kg in mice. This conclusion is made through studies on the biodistribution and 90-day long term in vivo clearance of the nanoplates. The liver and spleen are dominant organs for accumulation of the nanoplates, which is mainly due to RES absorption. 93% of the nanoplates are cleared after 90 days of treatment. Concentrations of Bi and Se in tumor tissue continuously increased until 72 h after intraperitoneal injection into mice. Such selective accumulation of Bi is utilized to enhance the contrast of X-ray computerized tomography (CT) images. Bi element concentrated in a tumor leads to damage on the tumor cells when exposed to gamma radiation. Growth of the tumor is significantly delayed and stopped in 16 days after the tumor is treated by radiation with Bi2Se3 nanoplates. This work clearly shows that Bi2Se3 nanoplates may be used for cancer radiation therapy and CT imaging. The nanoplates deserve further study for biological and medical applications.
- Subjects
BISMUTH compounds; CANCER treatment; RADIOTHERAPY; CHALCOGENIDES; COMPUTED tomography; NANOSTRUCTURED materials testing
- Publication
Advanced Functional Materials, 2014, Vol 24, Issue 12, p1718
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201302312