We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
c- fos elimination compensates for disabled- 2 requirement in mouse extraembryonic endoderm development.
- Authors
Yang, Dong-Hua; Smith, Elizabeth R.; Cai, Kathy Qi; Xu, Xiang-Xi
- Abstract
Disabled-2 (Dab2) is expressed in primitive endoderm cells as they are differentiating from the inner cell mass and dab2 deficiency in mice results in lethality at E5.5-E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c-Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5.5 dab2 (−/−): c- fos (−/−) embryos, indicating that the primitive endoderm defect due to the loss of Dab2 is rescued by deletion of the c- fos gene. The lethality of the double knockout embryos was delayed until E9.5-E10.5 and the defective embryos failed to undergo organogenesis. We conclude that Dab2 plays a role in epithelial organization by suppression of c-Fos expression and suggest that unsuppressed c-Fos can lead to disruption of primitive endoderm epithelial organization, yet an additional dab2 function is required for later organogenesis. Developmental Dynamics 238:514-523, 2009. © 2009 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2009, Vol 238, Issue 3, p514
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.21856