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- Title
Distinct expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta.
- Authors
Nie, Guiying; Hale, Kathryn; Li, Ying; Manuelpillai, Ursula; Wallace, Euan M.; Salamonsen, Lois A.
- Abstract
Mammalian embryos cannot survive without the placenta. Development of the human placenta requires trophoblast proliferation, differentiation, and invasion as well as highly coordinated modulation of the maternal uterus. HtrA1 is a member of the recently identified mammalian HtrA (high temperature requirement factor A) serine protease family with a high level of expression in the placenta. In this study, we examined whether HtrA1 expression (mRNA and protein) is associated with placental development in the human. HtrA1 is up-regulated in both endometrial glands and decidual cells during endometrial preparation for embryo implantation and during first-trimester pregnancy at placentation. HtrA1 expression was also detected in certain trophoblast subtypes during early pregnancy. The villous syncytiotrophoblast and cytotrophoblast showed the strongest expression while the interstitial extravillous trophoblast showed the lowest or no expression of HtrA1. The distinct distribution of HtrA1 at the maternal-trophoblast interface suggests that HtrA1 may play a role in placental development. Developmental Dynamics 235:3448-3455, 2006. © 2006 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2006, Vol 235, Issue 12, p3448
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.20999