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- Title
The synthesis of [1-<sup>14</sup>C]2-(1 H-tetrazol-5-yl)acetic acid.
- Authors
Maxwell, Brad D.; Tran, Scott B.
- Abstract
Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1-14C]2-(1 H-Tetrazol-5-yl)acetic acid was required as an intermediate in the synthesis of a development candidate as part of a discovery phase program to complete metabolic profiling studies. [1-14C]2-(1 H-Tetrazol-5-yl)acetic acid was prepared in 4 steps overall and in 3 radiochemical steps from K14CN in an overall 32% radiochemical yield.
- Subjects
ACETIC acid; HETEROCYCLIC compounds; TETRAZOLIUM compounds; RADIOCHEMICAL analysis; CHEMICAL synthesis; CARBOXYLIC acids
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2017, Vol 60, Issue 1, p49
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3472