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- Title
Effect of biological implant surface coatings on bone formation, applying collagen, proteoglycans, glycosaminoglycans and growth factors.
- Authors
Stadlinger, Bernd; Pilling, Eckart; Mai, Ronald; Bierbaum, Susanne; Berhardt, Ricardo; Scharnweber, Dieter; Eckelt, Uwe
- Abstract
The aim of the present study was to evaluate six different implant surface coatings with respect to bone formation. Being major structural components of the extracellular matrix, collagen, the non-collagenous components decorin/chondroitin sulphate (CS) and the growth factors TGF-β1/BMP-4 served in different combinations as coatings of experimental titanium implants. Eight miniature pigs received each six implants in the mandible. The implant design showed two circular recesses along the length axis. Three, four, five and six weeks after implant placement, the animals were sacrificed in groups of two. Bone-implant contact (BIC) was evaluated along the outer implant surface and within the recesses. Bone volume was determined by synchrotron radiation micro computed tomography (SRμCT) for one implant of each surface state, 6 weeks after placement. At each week of observation, collagen/CS or collagen/CS/BMP-4 coated implants showed the highest BIC of all surface states. This was statistically significant at week five ( p = 0.030, p = 0.040) and six ( p = 0.025, p = 0.005). SRμCT measurements determined the highest bone volume for a collagen/CS coated implant. The results indicate that collagen/CS and collagen/CS/BMP-4 lead to a higher degree of bone formation compared to other ECM components.
- Subjects
GLYCOSAMINOGLYCANS; GROWTH factors; COLLAGEN; SURFACE coatings; PROTEOGLYCANS; TITANIUM; ARTIFICIAL implants
- Publication
Journal of Materials Science: Materials in Medicine, 2008, Vol 19, Issue 3, p1043
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-007-3077-7